Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 44, Pages 13049-13052Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201506323
Keywords
C-H activation; amides; oximes; rhodium; synthetic methods
Categories
Funding
- NSFC [21272231, 21402190, 21472186]
- Postdoctoral Science Foundation of China [2015M571333]
- Dalian Institute of Chemical Physics, Chinese Academy of Sciences
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Nitrogenation by direct functionalization of CH bonds represents an important strategy for constructing CN bonds. Rhodium(III)-catalyzed direct amidation of unactivated C(sp(3))H bonds is rare, especially under mild reaction conditions. Herein, a broad scope of C(sp(3))H bonds are amidated under rhodium catalysis in high efficiency using 3-substituted 1,4,2-dioxazol-5-ones as the amide source. The protocol broadens the scope of rhodium(III)-catalyzed C(sp(3))H activation chemistry, and is applicable to the late-stage functionalization of natural products.
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