Journal
CLINICAL NEUROPSYCHOLOGIST
Volume 23, Issue 6, Pages 944-961Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/13854040802681664
Keywords
Alzheimer's disease; Vascular dementia; Binswanger's disease; Subcortical dementia; Episodic memory; The Philadelphia (repeatable) Verbal Learning Test (PrVLT)
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K23NS060660] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG021362, R03AG026610, R03AG027480, K23AG030962, P30AG013846] Funding Source: NIH RePORTER
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In patients with dementia, leukoaraiosis (LA) was hypothesized to result in differential patterns of impairment on a verbal serial list-learning test. Using a visual rating scale, 144 dementia patients with ischemic scores 4 were re-categorized as having mild (n = 73), moderate (n = 44), or severe LA (n = 27). Mild LA was predicted to be associated with an amnestic list-learning profile, while severe LA was predicted to be associated with a dysexecutive profile. List-learning performances were standardized to a group of healthy older adults (n = 24). Analyses were conducted on a set of four factors derived from the list-learning paradigm, as well as error scores. Data indicate that LA severity is an important marker for understanding list learning in dementia.
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