Journal
CLINICAL NEUROPHYSIOLOGY
Volume 129, Issue 11, Pages 2315-2324Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2018.08.020
Keywords
EEG coherence; First psychotic episode; Schizophrenia; Schizoaffective disorder; Resting state; Mental arithmetic task
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Funding
- European Regional Development Fund
- Czech Research Council [AZV 17-32957A]
- Russian Academy of Sciences
- project Sustainability for the National Institute of Mental Health [LO1611]
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Objectives: To evaluate the coherence values of the cortical bands in patients with first episode schizophrenia and schizoaffective disorder during the performance of a mental arithmetic task. Method: We analysed EEG coherence in the resting state and subsequently while counting down from 200 in steps of 7 in 32 first episode schizophrenia patients (SZ), 32 patients with first episode schizoaffective disorder (SA) and 40 healthy controls (HC). Results: Task performance in HC is characterised by decreased coherence in the alpha bands and increased coherence in the beta 2 and gamma bands in frontal sites. In SZ, coherence decreases in the alpha band, whereas in SA it substantially increases in the alpha, betal, beta 2 and gamma bands. Conclusions: Despite no differences in performance on a behavioural level, SA patients demonstrate a paradoxical increase in both low and fast frequency bands during the performance of a mental arithmetic task, while, patients with SZ show a decreased coherence in the alpha band, presumably alluding to the excessive excitatory (in SA) and inhibitory (in SZ) mechanisms in cognitive processing. Significance: The current study provides evidence for the distinction of neurophysiological mechanisms of cognitive processing between SZ and SA. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
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