Journal
CLINICAL NEUROPHYSIOLOGY
Volume 125, Issue 7, Pages 1459-1470Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2013.11.017
Keywords
Auditory neuropathy spectrum disorder (ANSD); Cortical auditory evoked potentials; P1 CAEP; Inter-trial coherence; Cortical phase synchrony; Sensorineural hearing loss; Development; Cortical maturation; Cochlear implant; Hearing aid
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Funding
- NIH [R01DC0625]
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Objective: Although brainstem dys-synchrony is a hallmark of children with auditory neuropathy spectrum disorder (ANSD), little is known about how the lack of neural synchrony manifests at more central levels. We used time-frequency single-trial EEG analyses (i.e., inter-trial coherence; ITC), to examine cortical phase synchrony in children with normal hearing (NH), sensorineural hearing loss (SNHL) and ANSD. Methods: Single trial time-frequency analyses were performed on cortical auditory evoked responses from 41 NH children, 91 children with ANSD and 50 children with SNHL. The latter two groups included children who received intervention via hearing aids and cochlear implants. ITC measures were compared between groups as a function of hearing loss, intervention type, and cortical maturational status. Results: In children with SNHL, ITC decreased as severity of hearing loss increased. Children with ANSD revealed lower levels of ITC relative to children with NH or SNHL, regardless of intervention. Children with ANSD who received cochlear implants showed significant improvements in ITC with increasing experience with their implants. Conclusions: Cortical phase coherence is significantly reduced as a result of both severe-to-profound SNHL and ANSD. Significance: ITC provides a window into the brain oscillations underlying the averaged cortical auditory evoked response. Our results provide a first description of deficits in cortical phase synchrony in children with SNHL and ANSD. (C) 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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