Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 27, Pages 7915-7919Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201501468
Keywords
multimodal imaging; organosilica; photodynamic therapy; rattle structures; upconversion nanoprobes
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Funding
- 973 program of MOST [2014CB845605]
- Special Project of National Major Scientific Equipment Development of China [2012YQ120060]
- NSFC [21201163, U1305244, 21325104]
- CAS/SAFEA International Partnership Program for Creative Research Teams
- Strategic Priority Research Program of the CAS [XDA09030307]
- NSF of Fujian Province [2013J05038]
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Lanthanide-doped upconversion nanoparticles (UCNPs) have shown great promise in versatile bioapplications. For the first time, organosilica-shelled -NaLuF4:Gd/Yb/Er nanoprobes with a rattle structure have been designed for dual-modal imaging and photodynamic therapy (PDT). Benefiting from the unique rattle structure and aromatic framework, these nanoprobes are endowed with a high loading capacity and the disaggregation effect of photosensitizers. After loading of -carboxyphthalocyanine zinc or rose Bengal into the nanoprobes, we achieved higher energy transfer efficiency from UCNPs to photosensitizers as compared to those with conventional core-shell structure or with pure-silica shell, which facilitates a large production of singlet oxygen and thus an enhanced PDT efficacy. We demonstrated the use of these nanoprobes in proof-of-concept X-ray computed tomography (CT) and UC imaging, thus revealing the great potential of this multifunctional material as an excellent nanoplatform for cancer theranostics.
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