Journal
CLINICAL NEUROPHYSIOLOGY
Volume 123, Issue 2, Pages 358-368Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2011.07.029
Keywords
Basal ganglia; GPi; Microelectrode recordings; Local field potential; Oscillations
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Funding
- Canadian Institutes of Health Research [MOP-42505]
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Objective: Deep brain stimulation in the globus pallidus internus (GPi) is used to alleviate the motor symptoms of both Parkinson's disease (PD) and dystonia. We tested the hypothesis that PD and dystonia are characterized by different temporal patterns of synchronized oscillations in the GPi, and that the dopaminergic loss in PD makes the basal ganglia more susceptible to oscillatory activity. Methods: Neuronal firing and local field potentials (LFPs) were simultaneously recorded from the GPi in four PD patients and seven dystonia patients using two independently driven microelectrodes. Results: In the PD patients, beta (11-30 Hz) oscillations were observed in the LFPs and the firing activity of similar to 30% of the neurons was significantly coherent with the LFP. However, in the dystonia group, the peak frequency of LFP oscillations was lower (8-20 Hz) and there was a significantly smaller proportion of neurons (similar to 10%) firing in coherence with the LFP (P < 0.001). Conclusions: These findings suggest that synchronization of neuronal firing with LFP oscillations is a more prominent feature in PD than in dystonia. Significance: This study adds to the growing evidence that dopaminergic loss in PD may increase the sensitivity of the basal ganglia network to rhythmic oscillatory inputs. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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