Journal
CLINICAL NEUROPHYSIOLOGY
Volume 122, Issue 9, Pages 1779-1787Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2011.01.053
Keywords
Continuous spikes and waves during slow wave sleep; Electrical status epilepticus during sleep; Slow waves; Sleep homeostasis; Epileptic encephalopathy
Categories
Funding
- Anna Muller Grocholski-Foundation
- Swiss National Science Foundation [PP00A3-114923]
Ask authors/readers for more resources
Objective: Encephalopathy related to electrical status epilepticus during slow wave sleep'' (ESES) is characterised by the electroencephalographic pattern of continuous spike waves during slow wave sleep (CSWS) and variable neuropsychological impairments. The synaptic homeostasis hypothesis predicts that the strength of synapses is decreased during sleep. The slope of slow waves during NREM sleep best reflects this downscaling''. Methods: In a retrospective case control study, we analysed the time course of the slope of EEG slow waves of nine patients with ESES. The patients showed continuous spike waves (> 85%) associated with regression or stagnation of cognitive functions. The data of the patient group were compared to nine healthy age and gender matched controls. Results: In control subjects we found the expected decrease of the slope of slow waves from the first to the last hour of sleep (17.2% decrease, p < 0.001). In contrast, patients showed no significant change in slope across the night. Conclusions: This finding may reflect a disruption of the downscaling process during sleep, which may contribute to the developmental regression in these children. Significance: Thus, our findings contribute to the understanding of the pathomechanisms leading to the regression observed in children with ESES and support the view that the goal of the treatment in children with ESES should not only be to reduce seizures, but also to resolve the continuous spike wave activity. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available