Related references
Note: Only part of the references are listed.Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer's disease
Kenji Fukunaga et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Substituted piperazines as nootropic agents: 2-or 3-phenyl derivatives structurally related to the cognition-enhancer DM235
Luca Guandalini et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Enantioselective Synthesis of Dialkylated N-Heterocycles by Palladium-Catalyzed Allylic Alkylation
Yoshitaka Numajiri et al.
ORGANIC LETTERS (2015)
Bespoke SnAP Reagents for the Synthesis of C-Substituted Spirocyclic and Bicyclic Saturated N-Heterocycles
Kimberly Geoghegan et al.
ORGANIC LETTERS (2015)
Enantioselective Synthesis of α-Secondary and α-Tertiary Piperazin-2-ones and Piperazines by Catalytic Asymmetric Allylic Alkylation
Katerina M. Korch et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Deactivation in Homogeneous Transition Metal Catalysis: Causes, Avoidance, and Cure
Robert H. Crabtree
CHEMICAL REVIEWS (2015)
Rings in Drugs
Richard D. Taylor et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among US FDA Approved Pharmaceuticals
Edon Vitaku et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Discovery of a Novel Class of Potent HCV NS4B Inhibitors: SAR Studies on Piperazinone Derivatives
Ramesh Kakarla et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
SnAP reagents for the one-step synthesis of medium-ring saturated N-heterocycles from aldehydes
Cam-Van T. Vo et al.
NATURE CHEMISTRY (2014)
SnAP Reagents for the Synthesis of Piperazines and Morpholines
Michael U. Luescher et al.
ORGANIC LETTERS (2014)
SnAP Reagents for the Transformation of Aldehydes into Substituted Thiomorpholines-An Alternative to Cross-Coupling with Saturated Heterocycles
Cam-Van T. Vo et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Ligand-Protein Interactions of Selective Casein Kinase 1δ Inhibitors
Scot Mente et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Overcoming Product Inhibition in Catalysis of the Intramolecular Schmidt Reaction
Hashim F. Motiwala et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Stereoretentive Pd-catalysed Stille cross-coupling reactions of secondary alkyl azastannatranes and aryl halides
Ling Li et al.
NATURE CHEMISTRY (2013)
Escape from Flatland 2: complexity and promiscuity
Frank Lovering
MEDCHEMCOMM (2013)
Catalytic Asymmetric Synthesis of Substituted Morpholines and Piperazines
Huimin Zhai et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Asymmetric Hydrogenation of Heteroarenes and Arenes
Duo-Sheng Wang et al.
CHEMICAL REVIEWS (2012)
Enantioselective construction of quaternary N-heterocycles by palladium-catalysed decarboxylative allylic alkylation of lactams
Douglas C. Behenna et al.
NATURE CHEMISTRY (2012)
The developability of heteroaromatic and heteroaliphatic rings - do some have a better pedigree as potential drug molecules than others?
Timothy J. Ritchie et al.
MEDCHEMCOMM (2012)
Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety
Nicholas A. Meanwell
CHEMICAL RESEARCH IN TOXICOLOGY (2011)
The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types
Timothy J. Ritchie et al.
DRUG DISCOVERY TODAY (2011)
The Medicinal Chemist's Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
Stephen D. Roughley et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Impact of ion class and time on oral drug molecular properties
Paul D. Leeson et al.
MEDCHEMCOMM (2011)
Privileged scaffolds for library design and drug discovery
Matthew E. Welsch et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2010)
The impact of aromatic ring count on compound developability - are too many aromatic rings a liability in drug design?
Timothy J. Ritchie et al.
DRUG DISCOVERY TODAY (2009)
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
Frank Lovering et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Asymmetric hydrogenation of heteroaromatic compounds
Yong-Gui Zhou
ACCOUNTS OF CHEMICAL RESEARCH (2007)
Discovery and synthesis of HIV integrase inhibitors: Development of potent and orally bioavailable N-methyl Pyrimidones
Cristina Gardelli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Fluorinated alcohols as solvents, cosolvents and additives in homogeneous catalysis
Ivan A. Shuklov et al.
SYNTHESIS-STUTTGART (2007)
Stereospecific cross-coupling of α-(thiocarbamoyl)organostannanes with alkenyl, aryl, and heteroaryl iodides
J. R. Falck et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species
Vincenzo Summa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Unveiling the booster effect of fluorinated alcohol solvents:: Aggregation-induced conformational changes and cooperatively enhanced H-bonding
Albrecht Berkessel et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Catalytic asymmetric synthesis of α-amino phosphonates using enantioselective carbon-carbon bond-forming reactions
S Kobayashi et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Copper(II) triflate-mediated addition reaction of α-oxygenated alkylstannanes to imines for the synthesis of vicinal-amino alcohol derivatives
H Kagoshima et al.
CHEMISTRY LETTERS (2003)