Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 37, Pages 10884-10888Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201505167
Keywords
aldehydes; cross-coupling; homogeneous catalysis; nitrogen heterocycles; SnAP reagents
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Funding
- ETH Research Grant [ETH-12 11-1]
- European Research Council (ERC) [306793]
- European Research Council (ERC) [306793] Funding Source: European Research Council (ERC)
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Commercially available SnAP (stannyl amine protocol) reagents allow the transformation of aldehydes and ketones into a variety of N-unprotected heterocycles. By identifying new ligands and reaction conditions, a robust catalytic variant that expands the substrate scope to previously inaccessible heteroaromatic substrates and new substitution patterns was realized. It also establishes the basis for a catalytic enantioselective process through the use of chiral ligands.
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