4.8 Article

Catalytic Synthesis of N-Unprotected Piperazines, Morpholines, and Thiomorpholines from Aldehydes and SnAP Reagents

Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 37, Pages 10884-10888

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201505167

Keywords

aldehydes; cross-coupling; homogeneous catalysis; nitrogen heterocycles; SnAP reagents

Funding

  1. ETH Research Grant [ETH-12 11-1]
  2. European Research Council (ERC) [306793]
  3. European Research Council (ERC) [306793] Funding Source: European Research Council (ERC)

Ask authors/readers for more resources

Commercially available SnAP (stannyl amine protocol) reagents allow the transformation of aldehydes and ketones into a variety of N-unprotected heterocycles. By identifying new ligands and reaction conditions, a robust catalytic variant that expands the substrate scope to previously inaccessible heteroaromatic substrates and new substitution patterns was realized. It also establishes the basis for a catalytic enantioselective process through the use of chiral ligands.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available