Journal
CLINICAL NEUROPHARMACOLOGY
Volume 33, Issue 1, Pages 52-54Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNF.0b013e3181bbf3a7
Keywords
hepatotoxicity; corticosteroids; adverse drug reactions; methylprednisolone
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Liver toxicity, although not mentioned among the possible adverse effects of corticosteroids. has been occasionally reported in literature. We observed 2 cases of hepatotoxicity after a high-dose methylprednisolone treatment of a demyelinating disease and evaluated the potential relationship in the light of available evidence. The first patient developed a histologically documented acute hepatitis and recovered after 3 weeks. In the second patient, a mild augmentation of liver enzymes occurred, followed by normalization in a few days. The causal relationship between hepatotoxicity, and methylprednisolone treatment was deemed probable in both cases. Careful review of the literature suggests that corticosteroid-induced liver damage may be more frequent than commonly believed.
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