Journal
CLINICAL NEUROPATHOLOGY
Volume 31, Issue 1, Pages 31-38Publisher
DUSTRI-VERLAG DR KARL FEISTLE
DOI: 10.5414/NP300410
Keywords
dysembiyoplastic neuroepithelial tumor; isocitrate dehydrogenase 1; oligodendrocyte-like cells; septum pellucidum; specific glioneuronal element
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Dysembryoplastic neuroepithelial tumor (DNT)-like neoplasms of the septum pellucidum are extremely rare. We reviewed 2 cases of DNT-like neoplasm of the septum pellucidum and specifically studied the immunohistochemical features and chromosomes 1p and 19q deletions. One case was a 26-year-old woman who complained of aggravated headache for 2 weeks. The other case was a 31-year-old female presenting with double vision for a month. Histological examinations showed that the lesions were composed of uniform oligodendrocyte-like cells (OLCs) with obvious floating neurons in a mucin-rich background. Immunohistochemical studies revealed that both tumors were diffusely positive for Synaptophysin and Olig2. Sporadic neurons were clearly positive for NeuN. Loss of chromosome 1p/19q and isocitrate dehydrogenase 1(IDH 1) mutations were not identified in both cases. It might indicate that these OLCs of DNT-like neoplasms were genetically different from glial tumors, although they showed close morphological similarities.
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