Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 18, Pages 5478-5482Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201500486
Keywords
C-H activation; carboxylic acids; cross-coupling; rhodium; synthetic methods
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Funding
- 973 Project from the MOST of China [2009CB825300]
- NSFC [20925207, 21002001]
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A rhodium(III)-catalyzed cross-coupling of benzyl thioethers and aryl carboxylic acids through the two directing groups is reported. Useful structures with diverse substituents were efficiently synthesized in one step with the cleavage of four bonds (C-H, C-S, O-H) and the formation of two bonds (C-C, C-O). The formed structure is the privileged core in natural products and bioactive molecules. This work highlights the power of using two different directing groups to enhance the selectivity of a double C-H activation, the first of such examples in cross-oxidative coupling.
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