Journal
CLINICAL NEPHROLOGY
Volume 81, Issue 3, Pages 203-209Publisher
DUSTRI-VERLAG DR KARL FEISTLE
DOI: 10.5414/CN107520
Keywords
acute kidney injury; favism; hemolysis; CD163; HO-1
Categories
Funding
- FIS (Programa Miguel Servet)
- ISCIII
- FEDER funds [CP04/00060, PS09/00447]
- Sociedad Espanola de Nefrologia [ISCIII-RETIC REDinREN/RD06/0016, Comunidad de Madrid/FRACM/S-BIO0283/2006]
- Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Redes RE-CAVA [RD06/0014/0035]
- ISCIII funds [PI10/00072]
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Intolerance to fava beans in subjects with glucose-6-phosphate-dehydrogenase deficiency (favism) may lead to severe hemolytic crises and decreased renal function. Renal biopsy findings exploring the molecular mechanisms of renal damage in favism have not been previously reported. We report a case of favism-associated acute kidney injury in which renal biopsy showed acute tubular necrosis and massive iron deposits in tubular cells. Interestingly, iron deposit areas were characterized by the presence of oxidative stress markers (NADPH-p22 phox and heme-oxigenase-1) and macrophages expressing the hemoglobin scavenger receptor CD163. In addition, iron deposits, NADPH-p22 phox, heme-oxigenase-1 and CD163 positive cells were observed in some glomeruli. These results identify both glomerular and tubular involvement in favism-associated acute kidney injury and suggest novel therapeutic targets to prevent or accelerate recovery from acute kidney injury.
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