Journal
CLINICAL NEPHROLOGY
Volume 77, Issue 4, Pages 329-331Publisher
DUSTRI-VERLAG DR KARL FEISTLE
DOI: 10.5414/CN106993
Keywords
continuous renal replacement therapy; pharmacokinetics; vancomycin; median inhibitory concentration; clearance
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Funding
- NIDDK NIH HHS [F32 DK093223] Funding Source: Medline
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Continuous renal replacement therapy (CRRT) is frequently used in the intensive care setting for the treatment of acute kidney injury. Dosing guidelines for many commonly used antibiotics were established during intermittent dialysis or in studies examining CRRT at lower blood and dialysis flow rates than are used in common practice. Herein we present data demonstrating frequent subtherapeutic levels of vancomycin in a population of patients on CRRT. Nephrology trainees should be educated as to the risks of under-dosing antibiotics in this population.
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