Journal
CLINICAL NEPHROLOGY
Volume 77, Issue 1, Pages 62-65Publisher
DUSTRI-VERLAG DR KARL FEISTLE
DOI: 10.5414/CN106859
Keywords
secondary focal segmental glomerulosclerosis; obstructive sleep apnea; obesity hypoventilation syndrome; proteinuria
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Associations between secondary focal segmental glomerulosclerosis and both obesity and obstructive sleep apnea have been previously described. Current theory suggests obesity induces glomerular hyperfiltration, leading to glomerulosclerosis. We describe a case of focal segmental glomerulosclerosis in the setting of severe obesity and obstructive sleep apnea with complete resolution of heavy proteinuria following treatment with bi-level positive airway pressure. The patient's proteinuria resolved completely with treatment of obstructive sleep apnea although the patient remained morbidly obese.
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