Journal
CLINICAL MICROBIOLOGY REVIEWS
Volume 27, Issue 2, Pages 302-345Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CMR.00111-13
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Funding
- Astellas
- Tornier
- Pocared
- Pradama
- Pfizer
- 3M
- BioFire
- nanoMR
- National Institutes of Health [R01 AR 056647, R01 AI 91594]
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Prosthetic joint infection (PJI) is a tremendous burden for individual patients as well as the global health care industry. While a small minority of joint arthroplasties will become infected, appropriate recognition and management are critical to preserve or restore adequate function and prevent excess morbidity. In this review, we describe the reported risk factors for and clinical manifestations of PJI. We discuss the pathogenesis of PJI and the numerous microorganisms that can cause this devastating infection. The recently proposed consensus definitions of PJI and approaches to accurate diagnosis are reviewed in detail. An overview of the treatment and prevention of this challenging condition is provided.
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