Journal
CLINICAL MICROBIOLOGY REVIEWS
Volume 25, Issue 1, Pages 193-+Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CMR.00013-11
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Funding
- National Institute of Allergy and Infectious Diseases, National Institutes of Health [R01 AI69568]
- National Institute of Dental and Craniofacial Research, National Institutes of Health [IR01DE20939, IR01DE14158, 5T32DE007309]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI069568] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE020939, T32DE007309] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE014158] Funding Source: NIH RePORTER
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Microorganisms coexist in a complex milieu of bacteria, fungi, archaea, and viruses on or within the human body, often as multifaceted polymicrobial biofilm communities at mucosal sites and on abiotic surfaces. Only recently have we begun to appreciate the complicated biofilm phenotype during infection; moreover, even less is known about the interactions that occur between microorganisms during polymicrobial growth and their implications in human disease. Therefore, this review focuses on polymicrobial biofilm-mediated infections and examines the contribution of bacterial-bacterial, bacterial-fungal, and bacterial-viral interactions during human infection and potential strategies for protection against such diseases.
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