Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 12, Pages 3817-3821Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201411701
Keywords
arylation; C-H activation; decarboxylation; heterocycles; rhodium catalysis
Categories
Funding
- NSCF [21431008, 21332001, 21302184, 21202164]
- 973 Program [2011CB932404, 2011CBA00501]
Ask authors/readers for more resources
A rhodium(III)-catalyzed carboxylic acid directed decarboxylative C-H/C-H cross-coupling of carboxylic acids with thiophenes has been developed. With a slight adjustment of the reaction conditions based on the nature of the substrates, aryl carboxylic acids with a variety of substituents could serve as suitable coupling partners, and a broad variety of functional groups were tolerated. This method provides straightforward access to biaryl scaffolds with diverse substitution patterns, many of which have conventionally been synthesized through lengthy synthetic sequences. An illustrative example is the one-step gram-scale synthesis of a biologically active 3,5-substituted 2-arylthiophene by way of the current method.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available