Journal
CLINICAL MICROBIOLOGY REVIEWS
Volume 22, Issue 2, Pages 370-+Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CMR.00048-08
Keywords
-
Categories
Funding
- NIAID NIH HHS [R01 AI076233] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Ask authors/readers for more resources
Following their discovery in the early 1970s, classical human leukocyte antigen (HLA) loci have been the prototypical candidates for genetic susceptibility to infectious disease. Indeed, the original hypothesis for the extreme variability observed at HLA loci (H-2 in mice) was the major selective pressure from infectious diseases. Now that both the human genome and the molecular basis of innate and acquired immunity are understood in greater detail, do the classical HLA loci still stand out as major genes that determine susceptibility to infectious disease? This review looks afresh at the evidence supporting a role for classical HLA loci in susceptibility to infectious disease, examines the limitations of data reported to date, and discusses current advances in methodology and technology that will potentially lead to greater understanding of their role in infectious diseases in the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available