Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 20, Issue 7, Pages O418-O420Publisher
WILEY-BLACKWELL
DOI: 10.1111/1469-0691.12441
Keywords
Dormancy; Mycobacterium tuberculosis; resuscitation promoting factors; sputum; treatment
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Funding
- Task Applied Science, Cape Town
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We investigated the effect of Mycobacterium tuberculosis culture supernatant added to sputum cultures collected during the first 8 weeks of anti-tuberculosis treatment. With ongoing treatment duration, time to culture positivity decreased significantly in supernatant-enriched cultures, possibly due to stimulation of dormant or slowly metabolizing M. tuberculosis cells.
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