Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 19, Issue 6, Pages 558-565Publisher
ELSEVIER SCI LTD
DOI: 10.1111/j.1469-0691.2012.03934.x
Keywords
CD4 T cells; human immunodeficiency virus; immune reconstitution; immunosenescence; vertically HIV-infected subjects
Categories
Funding
- Spanish AIDS Research Network of Excellence (RIS
- Red de Investigacion en SIDA) [RD06/0006/0021, RD09/0076/00103, RD06/0006-0035]
- Consejeria de Salud of Junta de Andalucia [PI-0366/07]
- Consejeria de Innovacion, Ciencia y Empresa [P10-CTS-6313]
- Fundacion para la Investigacion y la prevencion del SIDA en Espana (FIPSE) [366884/07, 240800/09, 300509]
- Fondos de Investigacion Sanitaria (FIS) [CP07/00240, CP07/00117, CP08/0172, CD10/00382]
- Comunidad de Madrid [S-SAL-0159-2006]
- Paediatric European Network for treatment of AIDS (PENTA)
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Clin Microbiol Infect Abstract Vertical transmission of human immunodeficiency virus (HIV) represents an important world-wide health problem although the incidence in developed countries has been drastically reduced by the extensive use of highly active antiretroviral therapy. Vertically HIV-infected subjects have been exposed to the virus during the maturation of their immune systems and have suffered a persistent chronic activation throughout their lifetime; the consequences of this situation for their immune system are not fully understood. The objective of this study was to analyse immunosenescence-related parameters in different CD4 T-cell subsets. Fifty-seven vertically HIV-infected subjects and 32 age-matched healthy subjects were studied. Activation (HLADR+), senescence (CD28CD57+) and proliferation (Ki67+) were analysed on different CD4 T-cell subsets: naive (CD45RA+CD27+), memory (CD45RO+CD27+), effector memory (CD45RO+CD27) and effector memory RA (CD45RA+CD27). Compared with healthy subjects, vertically HIV-infected subjects showed increased naive and memory CD4 T-cell frequencies (p0.035 and p0.010, respectively) but similar frequencies of both effector subsets. Whereas naive CD4 T cells were not further altered, memory CD4 T cells presented increased levels of senescence and proliferation markers (p<0.001), effector memory CD4 T cells presented increased levels of activation, senescence and proliferation markers (p<0.001) and effector memory RA CD4 T cells presented increased levels of activation and senescence (p<0.001) compared with healthy subjects. Despite long periods of infection, vertically HIV-infected subjects show specific patterns of immunosenescence, revealing a preserved CD4 T-cell homeostasis for subset differentiation and distribution. Nevertheless, excepting the naive subpopulation, all subsets experienced some immunosenescence, pointing to uncertain consequences of the future aging process in these subjects.
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