Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 18, Issue 5, Pages 432-438Publisher
ELSEVIER SCI LTD
DOI: 10.1111/j.1469-0691.2012.03815.x
Keywords
Antibiotic; carbapenem; Gram-negatives; resistance; ss-lactams
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Funding
- INSERM [U914]
- European Society for Clinical Microbiology and Infectious Diseases (ESCMID)
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Carbapenem-hydrolysing beta-lactamases are the most powerful beta-lactamases, being able to hydrolyse almost all beta-lactams. They are mostly of the KPC, VIM, IMP, NDM and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern, as these carbapenemase producers are multidrug-resistant. Detection of infected patients and of carriers are the two main approaches for prevention of their spread. Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies. The detection of carriers still relies mostly on the use of screening culture media.
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