Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 17, Issue 9, Pages 1444-1447Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1469-0691.2011.03572.x
Keywords
Colistin resistance; colonization; Klebsiella pneumoniae; KPC-3; ST258
Categories
Funding
- MIUR [2007SCA9RK]
Ask authors/readers for more resources
We report the first outbreak caused by colistin-resistant Klebsiella pneumoniae producing KPC-3 carbapenamase in two Italian hospitals. This spread occurred in 1 month, and was caused by eight colistin-resistant and carbapenem-resistant Klebsiella pneumoniae isolates from eight patients. A further three isolates were obtained from the intestinal tract and pharyngeal colonization. All isolates were multidrug-resistant (MDR), including being resistant to colistin, but they were susceptible to gentamicin and tigecycline. PCR detection showed that all isolates harboured the bla(KPC-3) gene associated with bla(SHV-11), bla(TEM-1) and bla(OXA-9). All K. pneumoniae isolates, genotyped by pulsed-field gel electrophoresis and multilocus sequence typing, belonged to the same sequence type (ST)258 clone. From our data and a review of the international literature, K. pneumoniae ST258 seems to be the most widespread genetic background for KPC dissemination in Europe.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available