Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 17, Issue 2, Pages 273-277Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1469-0691.2010.03266.x
Keywords
Chemotherapy; leukaemia; mould infection; non-Aspergillus mould; stem cell transplantation
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P>We describe three invasive mould infections due to Hormographiella aspergillata occurring within 1 year in patients undergoing treatment for acute leukaemia. All patients presented with pulmonary infiltrates; one patient additionally had cerebral and ocular involvement. Diagnostic procedures included bronchoalveolar lavage in all, and video-assisted thoracoscopic surgery in two patients. Susceptibility testing was performed by E-test and detected low minimal inhibitory concentrations for voriconazole and amphotericin B. All patients received systemic antifungal therapy; however, all of them died. Despite this cluster of three cases of an unusual mould infection, no hospital source was detected.
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