Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 14, Issue 4, Pages 384-388Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1469-0691.2007.01947.x
Keywords
clindamycin; fusidic acid; linezolid; oxacillin; Panton-Valentine leukocidin; rifampicin; Staphylococcus aureus
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The capacity of Staphylococcus aureus strain LUG855 to release Panton-Valentine leukocidin (PVL) in the presence of sub-inhibitory concentrations of anti-staphylococcal drugs was examined. Oxacillin enhanced PVL release 2.5-fold, while clindamycin, linezolid, fusidic acid and rifampicin were inhibitory, and vancomycin, pristinamycin, tetracycline, ofloxacin and co-trimoxazole had no effect. In combination with oxacillin, sub-inhibitory concentrations of clindamycin or rifampicin inhibited PVL induction significantly, linezolid was less inhibitory, and fusidic acid did not inhibit PVL induction by oxacillin. These data support the use of oxacillin in combination with clindamycin, rifampicin or linezolid for the treatment of PVL-positive S. aureus infections.
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