Journal
CLINICAL LIPIDOLOGY
Volume 7, Issue 2, Pages 215-222Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/CLP.12.8
Keywords
cholesterol; hyperlipidemia; inulin; meta-analysis; triglycerides
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Funding
- National Science Fund for Distinguished Young Scholars [31125021]
- National High Technology and Development Program of China [2011AA100901, 2011AA100902]
- Doctor Candidate Foundation of Jiangnan University [JUDCF10052]
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Inulin has been shown to be an effective therapeutic for reducing total serum cholesterol and triglycerides in clinical trials with modest sample sizes. A systematic literature search of several databases was conducted for studies that investigated the efficacy of inulin on the plasma lipid profile of subjects. A random-effects model was used to calculate the weighted mean difference and 95% CI as the difference between the mean for the inulin and control groups. The pooled mean net changes in total cholesterol, LDL-C, HDL-C and triglycerides of hyperlipidemic and normolipidemic subjects with inulin compared with controls were calculated. The results indicate that a diet rich in inulin has beneficial effects on total cholesterol and LDL-C, as well as triglyceride concentration in the plasma of hyperlipidemic subjects, and has no effects on plasma lipids in normolipidemic subjects.
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