Journal
CLINICAL LIPIDOLOGY
Volume 4, Issue 2, Pages 245-265Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/CLP.09.8
Keywords
adipogenesis; adipogenic differentiation; myogenesis; satellite cell; skeletal muscle; stem cell
Categories
Funding
- Fondazione Citta della Speranza, Onlus
- Ricerca Sanitaria Finalizzata Regione Veneto [2007BRR57M_004]
Ask authors/readers for more resources
Satellite cells (SCs) are undifferentiated skeletal muscle cells that allow muscular growth and regeneration. Since their first description, SCs were simply considered myogenic precursors, but now it is widely accepted that SCs are a heterogeneous stem cell population characterized by plasticity and self-renewal. In this report we focus on SCs capacity to undergo adipogenic differentiation both spontaneous and induced by adipogenic factors. Understanding SC behavior is especially important because their adipogenic potential could represent a pathophysiological explanation for the intramuscular fat depots and associated insulin resistance that characterize many metabolic diseases and age-related sarcopenia. Moreover, SC are a therapeutic promise for neuromuscular diseases in the context of tissue engineering, representing an interesting cell source for implantation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available