Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 380, Issue -, Pages 132-139Publisher
ELSEVIER
DOI: 10.1016/j.jmmm.2014.10.146
Keywords
Magnetite nanoparticle; PEGylated nanomagnets; Superhydrophilic coating; Colloid stability; Biomedical application
Funding
- OTKA [NK 84014]
- European Union
- State of Hungary
- National Excellence Program [TAMOP-4.2.4.A/2-11/1-2012-0001]
Ask authors/readers for more resources
Fabrication of PEG coating on magnetite nanoparticles (MNPs) is one of the most favoured ways to ensure biocompatibility. Surface modification of magnetite by an own-prepared comb-like PEG-copolymer (PEGA-AA) was compared with two commercially available ones (carboxy-PEG (PEG-C) and phosphate-PEG (PEG-P)). ATR FT-IR data revealed that all polymers form complexes on the surface of MNPs. Electrophoresis and dynamic light scattering (DLS) experiments showed that both the type and quantity of the polymers' anchoring groups influence the aggregation of coated nanomagnets. PEG-C shell does not provide excess negative charges, so magnetite particles became aggregated. However PEG-P and PEGA-AA gradually modify the surface: neutralizing the originally positively charged MNPs below loading 0.5 mmol/g, while above it a polyanionic layer forms on nanomagnets dispersing them in salty media at pH similar to 6.5. The PEGA-AA comb-like copolymer is more efficient for MNPs PEGylation clue to the uniform distribution of carboxylates and PEG chains along the carbon skeleton. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available