Journal
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Volume 6, Issue 10, Pages 2439-2443Publisher
AMER SOC NEPHROLOGY
DOI: 10.2215/CJN.01010211
Keywords
-
Categories
Funding
- ISN-Amgen
- Laboratory of Kidney Pathology
- National Center for Research Resources (NCRR)/NIH [M01RR00051, M01RR00069]
- NIH/NCRR Colorado CTSI [ULI RR025780]
- NIH(NIDDK) [DK34039]
- Zell Family Foundation
Ask authors/readers for more resources
Background and objectives The purpose of this study was to determine whether glomerular hyperfiltration (GH) occurring early in autosomal dominant polycystic kidney disease (ADPKD) is indicative of more rapid disease progression in children. Design, setting, participants, & measurements One hundred eighty children with ADPKD (ages 4 to 18 years) with normal renal function were examined by renal ultrasound. Renal volume was calculated using a standard formula for a modified ellipsoid. Creatinine clearance was calculated from serum creatinine and 24-hour urine creatinine. GH was defined as creatinine clearance >= 140 ml/min per 1.73 m(2). Results Thirty-two children had GH (mean age 11.4 +/- 3.6 years) and 148 had normal renal function (mean age 10.8 +/- 3.9 years). Patients with GH at baseline demonstrated an increased rate of total renal volume growth (beta: rate of change = +19.3 +/- 10.8 cm(3)/year) over 5 years compared with those without GH at baseline (beta = -4.3 +/- 7.7 cm(3)/year), P = 0.008. Those with GH at baseline experienced a faster decline in creatinine clearance in subsequent years (beta = 5.0 +/- 0.8 ml/min per 1.73 m(2) per year) compared with those without GH at baseline (beta = +1.0 +/- 0.4 ml/min per 1.73 m(2) per year), P < 0.0001. Conclusions This study revealed that occurrence of CH in ADPKD children is associated with a significantly faster decline in renal function and higher rate of kidney enlargement over time. GH combined with the increased renal volume may therefore be used as an early marker for a more severe progression of ADPKD in children. J Am Soc Nephrol 6: 2439-2443, 2011. doi: 10.2215/CJN.01010211
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available