Synthesis of water-dispersed magnetic nanoparticles (H2O-DMNPs) of β-cyclodextrin modified Fe3O4 and its catalytic application in Kabachnik-Fields multicomponent reaction

Water dispersed magnetic nanoparticles (H2O-DMNPs) of beta-cyclodextrin modified Fe3O4 were successfully synthesized. beta-Cyclodextrin acts as stabilizer and structure directing agent of Fe3O4. Subsequently, the dispersion of Fe3O4@beta-CD was applied for the Kabachnik-Fields multicomponent reaction through three-component synthesis of an amine, aldehyde, and dimethylphosphonate. beta-CD had also a drastic effect in accelerating the catalysis of phosphonate synthesis. By this protocol, phosphonate derivatives were synthesized in high yields and the catalyst was recycled for 10 successful runs. (C) 2015 Elsevier B.V. All rights reserved.