Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 380, Issue -, Pages 315-320Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2014.09.035
Keywords
Magnetic drug delivery; Thermosensitive; Curcumin release; Proton relaxation; Magnetic hyperthermia; MTT assay
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A dual stimuli sensitive magnetic hyperthermia based drug delivery system has been developed for targeted cancer treatment. Thermosensitive amine terminated poly-N-isopropylacrylamide complexed with pH sensitive chitosan nanoparticles was prepared as the drug carrier. Folic acid and fluorescein were tagged to the nanopolymer complex via N-hydroxysuccinimide and ethyl-3-(3-dimethylaminopropyl) carbodiimide reaction to form a fluorescent and cancer targeting magnetic carrier system. The formation of the polymer complex was confirmed using infrared spectroscopy. Gadolinium doped nickel ferrite nanoparlicles prepared by a hydrothermal method were encapsulated in the polymer complex to form a magnetic drug carrier system. The proton relaxation studies on the magnetic carrier system revealed a 200% increase in the T1 proton relaxation rate. These magnetic carriers were loaded with curcumin using solvent evaporation method with a drug loading efficiency of 86%. Drug loaded nanoparLicles were tested for their targeting and anticancer properties on four cancer cell lines with the help of MIT assay. The results indicated apoplosis of cancer cell lines within 3 h of incubation. (C) 2014 Elsevier BM. All rights reserved
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