Journal
CLINICAL JOURNAL OF PAIN
Volume 30, Issue 4, Pages 301-306Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/AJP.0b013e31829ca4fc
Keywords
forehead cooling; locus coeruleus; ipsilateral pain modulation; complex regional pain syndrome
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Funding
- National Health and Medical Research Council of Australia (NHMRC) [APP1030379]
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Objectives: The aim of this study was to determine whether a central disturbance in somatosensory processing contributes to limb pain in complex regional pain syndrome (CRPS). Methods: In 37 patients with CRPS, the effect of cooling the ipsilateral forehead on pain in the affected limb was compared with the effect of cooling the contralateral forehead. In addition, symptoms associated with cold-evoked limb pain were explored. Results: Limb pain generally increased when the ipsilateral side of the forehead was cooled but did not change when the contralateral side of the forehead was cooled. Increases were greatest in patients with heightened sensitivity to cold, brushing, and pressure-pain in the ipsilateral forehead, in patients with heightened sensitivity to pressure-pain in the limbs, and in patients with chronic symptoms. In contrast, sensitivity to light touch was diminished in the CRPS-affected limb of patients whose limb pain remained unchanged or decreased during ipsilateral forehead cooling. Conclusions: These preliminary findings suggest that a central disturbance in sensory processing and pain modulation, which extends beyond the affected limb to the ipsilateral forehead, contributes to symptoms in a subgroup of patients with CRPS.
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