Journal
CLINICAL INFECTIOUS DISEASES
Volume 59, Issue 4, Pages 545-548Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciu323
Keywords
ciHHV-6; HHV-6; X-SCID; hemophagocytic syndrome; thrombotic microangiopathy
Categories
Funding
- Ministry of Health, Labour, and Welfare of Japan [H25 Shinko-Ippan-015, H23 Nanchi-Ippan-003, H25 Nanchitou-Menneki-Ippan-105]
- Japan Society for the Promotion of Science [22590426]
- Ministry of Education, Culture, Sciences, and Technology in Japan [23390270, 23390271]
- Grants-in-Aid for Scientific Research [25460578, 23390270, 24390085, 26670171, 23390271, 22590426] Funding Source: KAKEN
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It has been unclear whether chromosomally integrated human herpesvirus 6 (ciHHV-6) can be activated with pathogenic effects on the human body. We present molecular and virological evidence of ciHHV-6A activation in a patient with X-linked severe combined immunodeficiency. These findings have significant implications for the management of patients with ciHHV-6.
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