Journal
CLINICAL INFECTIOUS DISEASES
Volume 60, Issue 3, Pages 432-437Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciu795
Keywords
diagnosis; active tuberculosis disease; latent Mtb infection; functional profile; CD8 T cells
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Funding
- NIAID NIH HHS [R01 AI083156] Funding Source: Medline
- NIH HHS [P51 OD011132] Funding Source: Medline
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Immune-based assays are promising tools to help to formulate diagnosis of active tuberculosis. A multiparameter flow cytometry assay assessing T-cell responses specific to Mycobacterium tuberculosis and the combination of both CD4 and CD8 T-cell responses accurately discriminated between active tuberculosis and latent infection.
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