Journal
CLINICAL INFECTIOUS DISEASES
Volume 58, Issue 10, Pages 1424-1429Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciu102
Keywords
visceral leishmaniasis; asymptomatic infection; immunity
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Funding
- NIAID NIH HHS [P50 AI074321, P50AI074321, U19 AI074321] Funding Source: Medline
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Visceral leishmaniasis (VL) is a serious parasitic disease, causing high morbidity and mortality in the developing world. The pathogenesis of VL is complex, and the clinical presentation ranges from asymptomatic infection to severe and fatal disease. Despite a wealth of research on the full-blown clinical VL syndrome, asymptomatic leishmania infections remain poorly understood. Asymptomatic infection could present a major challenge for control programs if its infectiousness is confirmed. In this viewpoint, we highlight the crucial knowledge gaps as well as the obstacles in research on asymptomatic leishmanial infection. Research in this area is essential for the development of more-effective VL control strategies.
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