Journal
CLINICAL INFECTIOUS DISEASES
Volume 60, Issue 4, Pages 598-604Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciu848
Keywords
malaria; prevention; pregnancy complication; time factors; Africa
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According to the current World Health Organization guidelines, the drug prevention of malaria during pregnancy does not adequately cover the first trimester of gestation in high-transmission areas. Although the pathophysiological mechanisms of early infections are not completely understood yet, a review of the most recent studies on the topic suggests that their consequences are serious in terms of maternal anemia and low birth weight. Consequently, there is a need to focus on the awareness of women in a period hard to access, to develop safe drugs to be used in the first trimester, and to consider preconceptional interventions in teenage girls, such as a new malaria vaccine to be used in pregnancy.
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