Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 379, Issue -, Pages 102-107Publisher
ELSEVIER
DOI: 10.1016/j.jmmm.2014.12.012
Keywords
Magnetic nanoparticles; Magnetic drug targeting; Particle trajectory
Funding
- Ministry of Human Resource Development (M.H.R.D.), Govt. of India
Ask authors/readers for more resources
A mathematical model is developed to describe the trajectories of a cluster of magnetic nanoparticles in a blood vessel for the application of magnetic drug targeting (MDT). The magnetic nanoparticles are injected into a blood vessel upstream from a malignant tissue and are captured at the tumour site with help of an applied magnetic field. The applied held is produced by a rare earth cylindrical magnet positioned outside the body. All forces expected to significantly affect the transport of nanoparticles were incorporated, including magnetization force, drag force and buoyancy force. The results show that particles are slow down and captured under the influence of magnetic force, which is responsible to attract the magnetic particles towards the magnet, It is optimized that all particles are captured either before or at the centre of the magnet (z <= 0) when blood vessel is very close proximity to the magnet (d = 2.5 cm). However, as the distance between blood vessel and magnet (d) increases (above 4.5 cm), the magnetic nanoparticles particles become free and they flow away clown the blood vessel. Further, the present model results are validated by the simulations performed using the finite element based COMSOL software. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available