Journal
CLINICAL INFECTIOUS DISEASES
Volume 57, Issue 4, Pages 604-607Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cit323
Keywords
HIV; Africa; resistance; switch; failure
Categories
Funding
- French National Agency for Research on AIDS and Viral Hepatitis [ANRS 12110]
- Ensemble pour une Solidarite Therapeutique Hospitaliere En Reseau (ESTHER)
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Our study in Cameroonian rural district hospitals showed that the immunologic and clinical failure criteria had poor performance to identify human immunodeficiency virus drug resistance in a timely manner. Switching to second-line antiretroviral therapy after 2 consecutive viral loads >= 5000 copies/mL, as recommended by the World Health Organization, appeared to be the most appropriate strategy.
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