Journal
CLINICAL INFECTIOUS DISEASES
Volume 55, Issue 11, Pages 1532-1549Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cis732
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Funding
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health (NIH) [U01 AI069497, R01 AI45462]
- Gilead Foundation
- World Health Organization (WHO)
- NIH [T32 AI007613]
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Tuberculosis is most common during a woman's reproductive years and is a major cause of maternal-child mortality. National guidelines for screening and management vary widely owing to insufficient data. In this article, we review the available data on (1) the global burden of tuberculosis in women of reproductive age; (2) how pregnancy and the postpartum period affect the course of tuberculosis; (3) how to screen and diagnose pregnant and postpartum women for active and latent tuberculosis; (4) the management of active and latent tuberculosis in pregnancy and the postpartum period, including the safety of tuberculosis medications; and (5) infant outcomes. We also include data on HIV/tuberculosis coinfection and drug-resistant tuberculosis. Finally, we highlight research gaps in tuberculosis in pregnant and postpartum women.
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