Journal
CLINICAL INFECTIOUS DISEASES
Volume 54, Issue 12, Pages 1778-1783Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cis307
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Funding
- Hong Kong University Grants Committee [AoE/M-12/06]
- Hong Kong University Research Council Strategic Research Theme of Public Health
- Harvard Center for Communicable Disease Dynamics from the National Institute of General Medical Sciences [U54 GM088558]
- Government of the Hong Kong SAR [PHE-2]
- MedImmune
- Roche
- Crucell MV
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We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.
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