Journal
CLINICAL INFECTIOUS DISEASES
Volume 55, Issue 12, Pages 1673-1676Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cis799
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Funding
- GlaxoSmithKline
- SanofiPasteur MSD
- Merck
- Pasteur Merieux Connaught
- Wyeth Lederle Vaccines and Pediatrics
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We reanalyzed the 7-valent pneumococcal conjugate vaccine trial FinOM for prevention of acute otitis media (AOM), with a focus on disease replacement due to other pathogens and AOM recurrence. We found evidence of replacement disease occurring early during the trial follow-up and little vaccine impact on recurrent overall AOM episodes.
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