Journal
CLINICAL INFECTIOUS DISEASES
Volume 56, Issue 1, Pages 40-50Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cis815
Keywords
HBV; HCV; cohort
Categories
Funding
- CDC Foundation
- Abbott Laboratories
- Abbott Pharmaceuticals
- Anadys Pharmaceuticals
- Bristol-Myers Squibb
- Conatus
- Eiger Biopharmaceuticals
- Exalenz BioScience
- Gilead Pharmaceuticals
- GlaxoSmithKline
- GlobeImmune
- Intercept Pharmaceuticals
- Merck
- Roche Pharmaceuticals
- Tibotec
- Vertex Pharmaceuticals
- Zymogenetics
Ask authors/readers for more resources
Background. The Chronic Hepatitis Cohort Study (CHeCS), a dynamic prospective, longitudinal, observational cohort study, was created to assess the clinical impact of chronic viral hepatitis in the United States. This report describes the cohort selection process, baseline demographics, and insurance, biopsy, hospitalization, and mortality rates. Methods. Electronic health records of >1.6 million adult patients seen from January 2006 through December 2010 at 4 integrated healthcare systems in Detroit, Michigan; Danville, Pennsylvania; Portland, Oregon; and Honolulu, Hawaii were collected and analyzed. Results. Of 2202 patients with chronic hepatitis B virus (HBV) infection, 50% were aged 44-63 years, 57% male, 58% Asian/Pacific Islander, and 13% black; and 5.1% had Medicaid, 16.5% Medicare, and 76.3% private insurance. During 2001-2010, 22.3% had a liver biopsy and 37.9% were hospitalized. For the 8810 patients with chronic hepatitis C virus (HCV) infection, 75% were aged 44-63 years, 60% male, 23% black; and 12% had Medicaid, 23% Medicare, and 62% private insurance. During 2001-2010, 38.4% had a liver biopsy and 44.3% were hospitalized. Among persons in care, 9% of persons with HBV and 14% of persons with HCV infection, mainly those born during 1945-1964, died during the 2006-2010 five-year period. Conclusions. Baseline demographic, hospitalization, and mortality data from CHeCS highlight the substantial US health burden from chronic viral hepatitis, particularly among persons born during 1945-1964.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available