Journal
CLINICAL INFECTIOUS DISEASES
Volume 51, Issue 5, Pages 571-574Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/655697
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI055752] Funding Source: NIH RePORTER
- NEI NIH HHS [K12 EY017269] Funding Source: Medline
- NIAID NIH HHS [R21 AI055752] Funding Source: Medline
- PHS HHS [K12EX017269] Funding Source: Medline
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After 6 biannual mass distributions of oral azithromycin for trachoma in Ethiopian communities, 76.8% (95% confidence interval [CI], 66.3%-85.1%) of nasopharyngeal Streptococcus pneumoniae isolates from children aged 1-5 years were resistant to macrolides. Twelve and 24 months after the last azithromycin treatment, resistance decreased to 30.6% (95% CI, 18.8%-40.4%; P < .001) and 20.8% (95% CI, 12.7%-30.7%; P < .001), respectively. Macrolide resistance decreases after antibiotic pressure is removed.
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