Journal
CLINICAL INFECTIOUS DISEASES
Volume 51, Issue 6, Pages 709-711Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/655892
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Funding
- Charles H. Hood Foundation
- David Rockefeller Center for Latin American Studies at Harvard University
- NEW AID Foundation
- von Clemm Foundation
- Bill & Melinda Gates Foundation
- National Heart, Lung, and Blood Institute [K01 HL080939]
- National Institute of Allergy and Infectious Diseases [K01 A1065836]
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We estimated the proportion of recurrence within 2 years among adults cured by individualized multidrug-resistant tuberculosis regimens in Peru. Among 310 individuals with at least 24 months of follow-up, 16 experienced an episode of recurrent tuberculosis. If we assume the worst for treatment effectiveness-that all 16 episodes were caused by the original tuberculosis strain-then 5.2% (95% confidence interval, 3.0%-8.2%) experienced true relapse. This is an upper-bound estimate of relapse on which new regimens must improve.
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