Journal
CLINICAL INFECTIOUS DISEASES
Volume 49, Issue 6, Pages 931-934Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/605497
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Funding
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health [N01 AI-15440, N01 AI-15441, 5R01AI1070091]
- Pfizer
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A prospective multicenter study of cryptococcal immune reconstitution inflammatory syndrome (IRIS) was conducted as a substudy of the Bacteriology and Mycology Study Group 3-01. Of 101 AIDS patients with cryptococcal meningitis who received highly active antiretroviral therapy (HAART), 13 experienced cryptococcal IRIS. No association between the timing of HAART initiation and the diagnosis of IRIS was identified. Increased baseline serum cryptococcal antigen (CrAg) titer was a risk factor for cryptococcal IRIS.
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