4.7 Article

Recurrent Burkholderia Infection in Patients with Chronic Granulomatous Disease: 11-Year Experience at a Large Referral Center

Journal

CLINICAL INFECTIOUS DISEASES
Volume 48, Issue 11, Pages 1577-1579

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1086/598937

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Funding

  1. Division of Intramural Research
  2. National Institute of Allergy and Infectious Diseases
  3. Clinical Center of the National Institutes of Health
  4. Cystic Fibrosis Foundation

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The epidemiology of Burkholderia infection in persons with chronic granulomatous disease is poorly understood. We used species-specific polymerase chain reaction-based assays and genotyping analyses to identify 32 strains representing 9 Burkholderia species among 50 isolates recovered from 18 patients with chronic granulomatous disease. We found that recurrent pulmonary infection with distinct Burkholderia strains is common in chronic granulomatous disease.

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