Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 23, Pages 6874-6877Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201500907
Keywords
chiral phosphines; enantioselectivity; kinetic resolution; organocatalysis; Rauhut-Currier reaction
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Funding
- 973 Programs [2011CB808600]
- National Natural Science Foundation of China [21372084, 21425205]
- Changjiang Scholars and Innovative Research Team in University (PCSIRT)
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A novel class of chiral sulfinamide phosphine catalysts (Xiao-Phos) are reported, which can be easily prepared from inexpensive commercially available starting materials. The Xiao-Phos catalysts showed good performance in enantioselective intramolecular Rauhut-Currier reactions, generating -methylene--butyrolactones in high yields with up to 99% ee under mild conditions. Moreover, kinetic resolution and parallel kinetic resolution were also observed with the use of two different substituted racemic precursors.
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