Journal
CLINICAL INFECTIOUS DISEASES
Volume 47, Issue 12, Pages 1575-1578Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/593196
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Funding
- Ministry of Education, China [B 07001]
- Lifu Educational Foundation
- National High Technology Research and Development Program of China [2006AA02Z452]
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The mechanism of systemic spread of H5N1 virus in patients with avian influenza is unknown. Here, H5N1 nucleoprotein and hemagglutinin were identified by immunohistochemistry in the nucleus and cytoplasm of neutrophils in the placental blood of a pregnant woman. Viral RNA was detected in neutrophils by in situ hybridization and enhanced real-time polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza.
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