Journal
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
Volume 16, Issue 5, Pages 728-735Publisher
WILEY-BLACKWELL
DOI: 10.1111/cid.12037
Keywords
biochemical coating; implants; laminin-1; titanium
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Funding
- Swedish National Graduate School in Odontological Science
- Swedish Research Council [K2009-52X-06533-27-3]
- Hjalmar Svenson Research Foundation
- Sylvan Foundation
- Wilhelm and Martina Lundgren Science Foundation
- Swedish Knowledge Foundation
- Council for Research and Development in Sodra Alvsborg, Sweden
- Royal Society of Arts and Sciences in Goteborg
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PurposeThe aim of this study was to assess the effect of implant coating with laminin-1 on the early stages of osseointegration in vivo. Materials and MethodsTurned titanium implants were coated with the osteoprogenitor-stimulating protein, laminin-1 (TL). Their osteogenic performance was assessed with removal torque, histomorphometry, and nanoindentation in a rabbit model after 2 and 4 weeks. The performance of the test implants was compared with turned control implants (T), alkali- and heat-treated implants (AH), and AH implants coated with laminin-1. ResultsAfter 2 weeks, TL demonstrated significantly higher removal torque as compared with T and equivalent to AH. Bone area was significantly higher for the test surface after 4 weeks, while no significant changes were detected on the micromechanical properties of the surrounding bone. ConclusionsWithin the limitations of this study, our results suggest a great potential for laminin-1 as a coating agent. A turned implant surface coated with laminin-1 could enhance osseointegration comparable with a bioactive implant surface while keeping the surface smooth.
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