Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 25, Pages 7275-7280Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201501478
Keywords
aggregation-induced emission; fluorescent probes; morphology effects; near infrared; tumor targeting
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Funding
- NSFC for Creative Research Groups [21421004]
- NSFC for Distinguished Young Scholars [21325625]
- National 973 Program [2013CB733700]
- NSFC/China
- Oriental Scholarship
- Shanghai Pujiang Program [13PJD010]
- Fok Ying Tong Education Foundation [142014]
- Fundamental Research Funds for the Central Universities [222201313010]
- Catalysis and Sensing for our Environment (CASE) network
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The rational design of high-performance fluorescent materials for cancer targeting in vivo is still challenging. A unique molecular design strategy is presented that involves tailoring aggregation-induced emission (AIE)-active organic molecules to realize preferable far-red and NIR fluorescence, well-controlled morphology (from rod-like to spherical), and also tumor-targeted bioimaging. The shape-tailored organic quinoline-malononitrile (QM) nanoprobes are biocompatible and highly desirable for cell-tracking applications. Impressively, the spherical shape of QM-5 nanoaggregates exhibits excellent tumor-targeted bioimaging performance after intravenously injection into mice, but not the rod-like aggregates of QM-2.
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